The effect of nanoparticle or ionic silver on cadmium accumulation by lettuce (Lactuca sativa) was investigated. The lettuce plants were grown in Hoagland solution amended with 0, 10, 100, 1000 μg/L nanoparticle silver or 0.1, 1, 10 μg/L ionic silver. Half of the lettuce were exposed to 50 μg/L ionic cadmium. After 35 days of exposure, wet weight, dry weight, cadmium, chlorophyll and malondialdehyde of leaves and roots of the lettuces were measured. Results show that except for the 1000 μg/L nanoparticle silver which increased cadmium concentration by about 200% (p<0.001) in lettuce roots, other concentrations of nanoparticle or ionic silver do not significantly change the cadmium concentration in either leaves or roots. Biomass, chlorophyll and malondialdehyde of the lettuces are not significantly changed either. Nanoparticle silver applied as agricultural fungicide in practical amounts will not lead to increased cadmium accumulation or detectable phytotoxicity symptoms in lettuce.